Influence of acute hypervolemic hemodilution on hemodynamic and coagulation status of elderly patients with radical resection of esophageal carcinoma
WEI Xiu-wu
SHANGGUAN Ming-hua
CHEN Zhen-fu
WU Shan-su
HUANG Shuo
FAN Shuang-chi
Abstract：Objective To evaluate the influence of acute hypervolemic hemodilution (AHH) on hemody-namic and coagulation status of elderly patients with radical resection of esophageal carcinoma. Methods Ninety patients aged 60～89 years undergoing elective esophageal carcinoma surgery under general anesthesia combined with epidural analgesia were randomly divided into 3 groups (n = 30). 30 minutes before anesthesia, group A was given 6% HES(200/0.5) 15～20 ml/kg, 20 ml/min; group B was given 6% VOLUVEN(HES 130/0.4); group C was given sodium lactate Ringer's solution. Mean arterial pressure (MAP), central vein pressure (CVP) and heart rate (HR) were recorded before AHH(t_1), at intubation(t_2), 10 minutes after intubation(t_3), 10 minutes after AHH(t_4), 3 hours after operation began(t_5) and at the end of operation (t_6). Changes of H6, Hct, PLT, PT, APTT and FIB were recorded. Result The levels of CVP, MAP increased (P < 0.05) in group A and B, and Hct decreased. As for coagulation function, PT, APTT, FIB either prolonged or decreased (P<0.05) at t_1; at t_3 and t_4, PCT decreased obviously(P < 0.01). There was not significant difference of hemodynamic and coagulation be-tween Group A and B. (P > 0.05). Volume of liquid and blood transfusion during operation in Croup C was higher than that in Group A and B. Conclusion AHH can effectively maintain hemodynamic stability and reduce blood transfusion.
Keywords：Esophageal neoplasmHemodilutionHemodynamicsCoagulation
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 139-141 )