Hyperthermic intraperitoneal chemotherapy combined with venous chemotherapy for low rectal cancer after anal sphincter preserving operation
GUAN Xiao-dong
LI Jian
LIU Xing-wei
Abstract：Objective To evaluate the effects of the hyperthermic peritoneal perfusion chemotherapy (HIPEC)combined with venous chemothempy for low rectal cancer after anal sphincter preserving operation.Methods Eighty-nine cases of low rectal cancer after anal sphincter preserving operation were randomly divided into experimental group(n=44)and control group(n=45).HIPEC was used four times,then the FOLFOX6 chemotherapy plan was carried out monthly for six months in experimental group.The control group was given FOLFOX6 chemothempy plan for six months only.The 2-year local recurrent rate was compared between the two groups.Results There were no severe complications occulted in two groups.The 2-year local recurrent rate in experimental group was 12.2%and was 37.5%in control group.The variation of 2-year local recurrent rote between the two groups achieved statistical significance(P<0.05).Conclusion HIPEC combined with venous chemotherapy can reduce the 2-year local recurrent rate of low rectal cancer after anal sphincter preserving operation.
Keywords：Rectal cancerIntraperitoneal therapyTemperature hypotonic chemotherapy
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 58-59 )