Expression and prognostic significance of focal adhesion kinase in hepatocellular carcinoma
CHEN Lian-zhou
LIU Min
OUYANG Wen-ting
ZHENG Lu
WANG Hua
LI Wen
WANG Qian
Abstract：Objective To investigate the expression and prognostic significance of focal adhesion kinase in hepatocellular carcinoma(HCC).Methods The expression of FAK wag detected by tissue microarray and immunohistochemical method in 82 HCC tissues,81 adjacent nontumor tissues and 25 normal liver tissues.Correlations of the expression of FAK with clinical pathologic features and prognosis were analyzed.Results The expression rate of FAK in HCC tissues(74.4%)was significantly higller than that in adjacent nontumor tissues(42.0%)(P<0.01)and innormal liver tissues(12.0%)(P<0.01).The expressions rate of FAK in adjacent nontumor tissues was significandy higher than that innormal liver tissues(P<0.01).The expression of FAK in HCC tissues was correlated with metastasis of carcinoma(P<0.05).The survival rate of FAK negative group in HCC tissues was significantly higher than that of positive group(P=0.012).Conclusion There is a hiish expression of FAK in HCC and may play an important role in occurrence,progression and prognosis of HCC.
Keywords：Liver neoplasmsHepatocellularImmunohistochemitry:Focal adhesion kinase
Publication Date：2010-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 9-10 )