Intravesical instillation of Hydroxycamptochecine combined with interferon for prevention of postoperative recurrence of bladder cancer(Report of 62 cases)
LUO Ying
YANG Dai-jun
ZHANG Zhi-yan
Abstract：Objective To evaluate intravesical instillation of Hydroxycamptochecine combined with interferon for prevention of postoperative recurrence of bladder cancer. Methods Sixty-two superficial bladder cases of TURP were treated with intravesical instillation of 15 mg hydroxycamptochecine combined 30×10~6 IU interferon dissolved in 40 ml normal saline. The drugs were retained in bladder for 2 hours. The drugs were given to bladder cancer patients postoperatively once a week for 6 weeks and subsequently once a month for 12 months. Kidney and liver function, blood counting, urinalysis and cystoscopy were taken periodically. The systemic and local reactions were recorded every time after the intravesical instillation.Results All of the 62 cases were followed up for 12 to 24 months with a mean of 19 months. The recurrence rate was 6.4%. There was no side effect. ConclusionsIntravesical instillation of Hydroxycamptochecine combined with interferon was effective for the prevention of postoperative recurrence of superficial bladder cancer with safety.
Keywords：BladdercancerHydroxycamptochecineInterferon
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)