Coexistent Hashimoto's thyroiditis with thyroid carcinoma
TIAN Xue-wu
WU Yan-fen
Abstract：Objective To investigate the clinicopathological features of coexistent Hashimoto's thyroiditis(HT) with thyroid carcinoma(TC) .Methods The clinicopathological data of 48 cases of HT and 9 cases of coexistent HT with TC from 1996 to 2008 were reviewed.Results The mean age was 45.2 years old. Female cases were more than male. In total 48 cases of HT, 9 cases had coexistent TC that was papillary thyroid carcinoma. The coexistent rate of HT with TC was 18.8%. Histological classification showed that 5 cases of papillary microcarcinoma, 2 classic variant, 1 follicular variant, and 1 oxyphilic cell variant. The transformation froms of follicular epithelial cell hyperplasia, to papillary hyperplasia to atypical hyperplasia and to carcinomatous change were observed in the tissues of coexistent HT with TC. Microscopic morphology of carcinomatous tissue of coexistent HT with TC was similar to that of ordinary papillary thyroid carcinoma.Conclusion There is a high coexistent rate of HT with TC. HT is closely associated with TC. Coexistent HT with TC occurs preferentially in the group of middle-aged women with no clinical symptom. HT is a potential malignant disease, and it should be paid more attention to, and multiple sampling in suspected area of HT specimen is recommended in order to miss any small tumor in clinical practice.
Keywords：Hashimoto's thyroiditisThyroid carcinomaClinicopathological
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)