Prostate stem cell antigen expression in gland epithelial cells of various endometriums
Abstract：Objective To analyze the expression of prostate stem cell antigen (PSCA) in gland epithelial cells of various endometriums. Methods The Immunohistochemistry, RT-PCR and Western Blot method were used to detect the PSCA expression in various endometriums. Results PSCA in endometrioid adenocarcinoma was mainly expressed in cancer cells, stromal cells, and no expression in muscle tissue. PSCA become increasing from Simple Hyperplasia (SH), Complex Hyperplasia(CH) and Atypical Hyperplasia (AH),particularly in AH (P<0.01). In the Endometrioid Adenocarcinoma (EAC), PSCA expression was associated with the differentiation grades (DG), myometrial invasion and surgical pathological stages. Poorer of DG, more deeper of myometrial invasion, and later of more of surgical pathological stages, more PSCA expression. The expression of PSCA was no significant difference between the proliferative phase and secretory phase. RT-PCR and Western Blot have got the same results with IHC. Conclusion PSCA may participate in the origin of precancerous lesions. PSCA expression may related to the bio-logical behavior of EAC and the development of EAC.
Keywords：Endometrioid adenocarcinomaProstate stem cell antigenImmunohistochemistryquantitative real-time PCRWestern Blot
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 940-943,前插2 )