Interstitial lung disease in patients with rheumatoid arthritis
YANG Fu-tang
ZHAO Meng
WANG Shu-yun
LI Yan
LU Pei-jin
HOU Qing-min
Abstract：Objective To investigate the prevalence and clinical manifestation of rheumatoid arthritis-inter-stitial lung disease(RA-ILD). Methods Forty-five inpatients with rheumatoid arthritis(RA) were enrolled. Serum rheumatoid factor (RF), C reactive protein (CRP), immunoglobulin (IgG, IgA, IgM), and compliment (C3, C4) were measured by immunoncphelometry. Antinuclear antibodies (ANAs) and anti-extractable nuclear antigen(anti-ENA) antibodies were measured by indirect immunofluorescence technique and Western blot. Arterial gas analysis included PaO2, PaCO2, and PA-zO2. The following pulmonary function tests were performed: tidal volume(VT), maximal vital-capacity (Vcmax), forced vital capacity (FVC), one second forced expiratory volume (FEV1), FEV1/FVC, maximal mid-expiratory flow(MMFF), maximal voluntary ventilation(MVV) and diffusing capacity CO (DLCO). Radiology examinations included chest X radiographs, hand radiographs and chest HRCT. Results abnormal findings included interlobular septal thickening, bronchovascular bundles thickening, sub pleura] lines, re-ticular appearances, ground glass capacity and honeycomb changes. HRCT was more sensitive than chest radio-graphy. Conclusions The incidence of RA-ILD is associated with the activity and severity of RA. DLCO and HRCT are important for early detection of disease.
Keywords：Rheumatoid arthritisInterstitial lung diseaseComputed tomographyRespiratory function test
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 881-883 )