Cytokines and type 2 diabetes insulin resistance
XU Bing
Abstract：Objective To study on the changes of the IL-6、IL-8、TNF-α、CRP in the type 2 diabetes with insulin resistance and the relation of plasma glucose or insulin resistance and cytokines. Methods (1) To assay the serum level of cytokines in 125 cases with type 2 diabetes mellitus(T2DM) and 40 normal controls. (2)To measure the level of fasting plasma glucose (FPG), hemoglobin A1c (HBA1c), fasting insulin (FINS), fasting C-peptide (FCP). (3)To analyze the relation of the level of FPG、HBA1c、FINS、FCP and cytokines. Results (1)The serum levels of cytokines in T2DM group were significantly higher than in control groups, IL-6、CRP、TNF-α in T2DM group with insulin resistance were significantly increase than in T2DM group without insulin resistance; (2)There was significantly positively correlation between insulin resistance and the increasing of cytokine levels. Conclusion There is an excess activation of cytokines in T2DM, which is significantly correlated with insulin resistance. Cyto-kines plays an important role in the occurrence and development of T2DM and insulin resistance.
Keywords：Type 2 diabetes mellitusInsulin resistanceCytokine
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 879-880 )