Relatienship among oxidized-LDLs, type 2 diabetes mellitns and metabolic syndrome
XU Xiao-ping
WANG Li-ping
YU Jia-ping
Abstract：Objective To discuss the relationship among oxidized-LDLs, type 2 diabetes mellitus (DM) and metabolic syndrome(MS). Methods Seventy-eight DM, 71 MS patients and 18 healthy controls were en-rolled. The systolic blood pressure, diastolic blood pressure, BMI, WHR was recorded, serum lipids, such as total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, apolipoprotein A & B100 and lipoprotein (a) were measured. The serum anti-oxLDL Ab (IgM and IgG) were measured by Immune ELISA. HDL subtype HDL-3 were detected by Dextran sulfate (50000 Dalton) sedimentation. Result The serum anti-oxLDL Ab in MS & DM patients were significantly higher than healthy controls (P < 0.05). The DM patients had higher levels of sub-type HDL-3 than the controls (P < 0.05). Serum anti-oxLDL Ab in DM patients increased gradually. Relative risk of people of high level of serum anti-oxLDL Ab was 2.57 times higher than that in control group (95% CI is 1.76-3.75, P = 0.000). Conclusion Serum anti-oxLDL Ab is closely related with Metabolic Syndrome and increases significantly in DM and MS patients. Serum HDL decreases in diabetic patients but subtype HDL-3 seems to in-crease. Meanwhile, serum anti-oxLDL Ab can be used as one of the laboratory items for diagnosis of MS.
Keywords：Oxidized LDLsDiabetes meilitusMetabolic syndrome
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 874-876 )