Relation among serum leptin, tumor necrosis factor, thyroid hormones and nutrition status in patients with chronic obstructive pulmonary disease
GU Xue-feng
SHEN Hong-tao
WENG Cui-ping
LI De-rong
JIN Yi-xin
SHAO Chuan-li
ZHI Li-min
Abstract：Objective To study the significance of serum leptin, thyroid hormones and tumor necrosis fac-tor-α(TNF-α) on malnutrition among chronic obstructive lung disease (COPD) patients. Methods A hundred and fourty-eight COPD patients in stable stage and 30 normal controls were studied. Nutritional parameters, including body mass index (BMI), percentage of normal body mass (NM%), triceps skin-fold thickness (TSF), mid-upper arm circumference(MAC),serum albumin(ALB) ,total lymphocyte counts(LYM) were determined. COPD patients were divided into malnutrition group(group Ⅰ) and non-malnutrition group (group Ⅱ)according to the nutritional parameter. Serum leptin levels and TNF-α were measured by ELISA, thyroid hormones (T3,T4, FT3, FT4, TSH) were tested by radioimmunoassay. The correlation among these parameters was analysed. Results There were sig-nificant difference on BMI,NW% ,TSF,MAC,ALB,LYM between group Ⅱ, control group and group Ⅰ. There were no significant difference on these parameters between group Ⅱ and control group. There were significant difference on serum leptin between group Ⅱ, control group and group Ⅰ. There were no significant difference on serum leptin be-tween group Ⅱ and control group. There were significant difference on TNF-α levels between group Ⅰ, group Ⅱ and control group. There were no significant difference on TNF-α levels between group Ⅰ and group Ⅱ. There were signifi-cant difference on T3,T4 between group Ⅱ, control group and group Ⅰ. There were significant difference on T4 between group Ⅱ and control group. Serum leptin in group Ⅰ and group Ⅱ showed a positive con-elation with BMI,NW% ,TSF,TNF-α and TSH. Conclusion Malnutrition correlate with serum leptin, thyroid hormones and TNF-α in COPD patients. Ser-am leptin levels were adjusted by TNF-α system. Serum leptin and hypothalamus-hypophysis-thyroid axial system regulate each other. Leptin, thyroid hormones and TNF-α contribute to the onset of malnutrition in COPD patients.
Keywords：Chronic obstructive pulmonary diseaseNutrition statusLeptinTumor necrosis factor-αThyroid hormones
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 864-867 )