Effects of tetrandrine on the expression of leptin and leptin receptor in acute exacerbation phase in chronic obstructive pulmonary diseases patients
PAN Hai-yan
WANG De-xi
LU Xiao-zhuo
ZENG Yu
ZHONG Hai-bo
DENG Si-jian
ZOU Shi-hai
WU Xiao-feng
Abstract：Objective To investigate the effect and role of the tetrandrine on the expression of leptin and leptin receptor of patient with COPD in systemic and local on acute exacerbation phase. Methods Eighty patients with COPD were randomly divided into two study groups: tetrandrine treating group(first group n =40) and routine treating group(second group n =40). The expression of leptin and the leptin receptor, IL-8 in serum and in induced sputum were measured by enzyme linked immunosorbent assay (ELISA), CRP was measured by turbidimetry. Blood gas analysis, pulmonary function testing was done routinely. Result There were no significant differences between two groups in the leptin,leptin receptor, IL-8, CRP in serum and the leptin,leptin receptor, IL-8 in the induced sputum before the treatment. Those indexes were significantly lower in the first group than in the the second group after treatment (P <0.05 and P <0.01). Significant correlations were found among the leptin in induced sputum and leptin in serum and leptin receptor, IL-8 in induced sputum. Leptin in induced sputum did not correlate with leptin receptor and IL-8 and CRP in serum. Conclusioions The leptin is involved in the system and airway flamma-tory prespose of the acute exacerbation phase with COPD. Tetrandrine can improve the systemic and local inflamma-tion and down-regulate the expression of leptin, leptin receptor and IL-8, CRP on the patient in acute exacerbation phase with COPD.
Keywords：Chronic obstructive pulmonary diseasesLeptinLeptin-receptorTetrandrine
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 833-835 )