Changes of heart fatty acld-bindlng protein concentrations after open heart surgery with different cardioplegia perfusion methods
WANG Yong-lian
WANG Zhong-min
WANG Yi
YAO Wen-jian
ZHAO Bao-sheng
LI Han-chen
Abstract：Objective To observe the changes of plasma heart fatty acid-binding protein (H-FABP) after open heart surgeries with different cardioplegia perfusion methods. Methods Forty congenital heart disease(CHD) patients underwent cardiac operation were randomly divided into two groups: cold crystalloid cardioplegia perfusiun group (Ⅰ,20 cases) and cold blood cardioplegia perfusion group(Ⅱ,20 cases). The plasma H-FABP concentration was detected by Enzyme-linked immunosorbent assay (ELISA) before and at different time points after CPB. Results The difference of plasma concentration of H-FABP preoperative was not significant between group Ⅰ and group Ⅱ. In both groups the plasma concentration of H-FABP during and after operation was higher than that before anesthesia. Conclusion Postoperative H-FABP concentration is significantly higher than preoperative H-FABP concentration. The level of plasma H-FABP concentration is not only related to the degree of myocardial damage but also related to the duration of aortic cross-clamping. H-FABP is a sensitive index for myocardial damage.
Keywords：Cadiopulmonary bypassHeart SurgeryHeart fatty acid-binding protein
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 609-611 )