Significance of serum resistin and APACHE Ⅱ score for evaluating the severity of critical patients
ZHOU Yong-qin
HUANG You-min
HE Ping
SONG Jing
Abstract：Objective To investigate the clinical significance of serum rosistin, Hs-CRP and APACHE Ⅱ score for evaluating the severity of patients. Methods The concentrations of resistin was measured by enzyme-Inked immunosorbent assay (ELISA). Hs-CRP was determined by rate nephelometry immunoassay. A clinical pro-spective self-control trial was performed, in which 80 patients admitted to ICU by SIRS were enrolled. Objects were divided into mild and severe trauma group according to APACHE Ⅱ score. The resisfin and Hs-CRP concentrations were determined on the 1st, 3rd and 5th day after admission and the APACHE Ⅱ score were assessed at the same time. Results The concentrations of resistin and Hs-CRP in severe trauma group were higher than those in the mild a-anma groups on the 1st day (all P < 0.05). The concentrations of Hs-CRP in the mild trauma group began to decrease on the 3rd day and the concentrations of rosistin began to decrease on the 5th day, meanwhile the APACHE Ⅱ score began to decrease too. The concentrations of resistin, Hs-CRP and APACHE Ⅱ scores in the severe trauma group concentrations kept increasing. There was a positive correlation between the concentrations of resistin and APACHE Ⅱ scores(r = 0.64, P < 0.01). There was also a positive correlation between the concentrations of Hs-CRPand APACHE Ⅱ scores(r = 0.61, P < 0.01), with also a positive correlation between the concentrations of resistin and Hs-CRP (r = 0.71, P < 0.01). Conclusion Dynamic measurement of rosistin and Hs-CRP concentra-tions with APACHE Ⅱ scores help evaluate the severity of critical patients.
Keywords：Systemic inflammatory response syndromeResistinHigh-sensitivity C-reactive proteinAPACHE Ⅱ score
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 595-597 )