Expression of IGF-1R and u-PALI in the laryngopharynx carcinoma
LI Wu-jie
SUN Yan
LI Da-jun
Abstract：Objective To investigate the expressions of IGF-1R protein and u-PA protein in the tissue of laryngopharynx carcinoma and to discuss the mechanism of pathogenesis, development, invasion and metastasis of laryngopharynx carcinoma. Methods IGF-1R protein and u-PA protein were detected by immunohistichemistry SP method in 55 laryngopharynx carcinoma cases,42 adjacnt to cancer cases and 40 epiglottis cyst cases.Results ① The positive expressions of IGF-1R and u-PA protein in the tissue of laryngopharynx carcinoma, in the tissue adja-cent to cancer and in the tissue of epiglottis cyst was decreased sequentially with significant differences (P < 0.01). ② The positive expressions of IGF-1R and u-PA protein in the tissue of metastasis and non-metastasis showed statistical difference(P<0.01).③ The IGF-1R expression was closely correlatde with the u-PA expression(P<0.01). Conclusion ①IGF-1R and u-PA are related to the pathogenesis and development of laryngopharynx carcinoma.② Detection of IGF-1R and u-PA in the tissue of laryngopharynx carcinoma might help evaluate the lymphatic metasta-sis of laryngopharynx carcinoma.
Keywords：Laryngopharynx carcinomaInsulin-like growth racer-1 receptorUrokinase typeplasminogen activatorImmunohistochemistry
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 592-594 )