Naloxone in treatment of severe craniocerebral trauma
SHI Wei
GUO Zhi-lin
Abstract：Objective To evaluate the efficacy of early application of Naloxone for treatment of severe craniocerebral trauma. Methods Sixty-two patients with severe craniocerebral trauma were divided into two groups: 30 cases were treated with naloxone and a control group of 32 cases without Naloxone. The clinical data, Glasgow coma scale(GCS) evaluation, consciousness recovery and respiratory failure recovery were observed. Results In treatment group, 10 cases(33.3%)recovered and 7 cases (23.32%)were dead. In controlled group there were 7 recovery (21.9%)and 12 death(37.5%). The recovery of consciousness and the recovery of respiratory failure in Naloxone group were also statistically lower than those in controlled group (P < 0.05). Conclusion Early applica-tion of Naloxone for severe craniocerebral trauma significantly reduces morbidity and mortality and improves the re-spiratory failure recovery.
Keywords：Craniocerebral TraumaNaloxoneOpioid peptides
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 534-535 )