Capillary gas chromatographic determination of four residual solvents in loperamide hydrochioride
GU Gao-qiang
ZHOU Kun
HUANG Shu-ping
YIN Bi-xi
Abstract：Objective To investigate a method of detecting four residual solvents in loperamide hydrochlo-fide. Methods The residual solvents in ioperamide hydrochloride included isopropanol, ethyl acetate, Methyl isobutyl ketone and methylbenzene. The concetrations were quantitatively detemined by headspace GC on J&W DB-624 column, FID detector. Nitrogen was used as the carry gas. The injector temperature was 200% and the detector temperature was 25℃, meanwhile the column temperature was programmed raised. Results The solvents were completely separated and the calibration CHives of each solvent showed good linear relationship within a certain range. Conclusion The method is sensitive, accurate and can be used for quality control.
Keywords：Loperamide hydrochlorideResidual solventsGas chromatogram
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 528-529 )