Effect of penehydidine on perioperative blood lactate levels and oxygen metabolismin in acute hemorrhagic shock patients
LI Wen-mei
ZHANG Shu
Shi Hai-yan
Abstract：Objective To evaluate the effect of penehyclidine on perioperative blood lactate levels and oxygen metabolismin in acute hemorrhagic shock patients. Methods Ninety-six patients with acute hemorrhagic shock was given laparotomy. Treatment group(n =48 ) and control group ( n = 48 ) were divided based on McLeod improved Wichmann-Hill pseudo-random number-generated hair-random sequence. Both groups underwent intubation general anesthesia. In treatment group patients were given penehyclidine 0.05 mg/kg. Respectively records were collected before infusion, 30 min, 60 min, 120 min after injection simultaneous blood lactate concentration (BL),and oxygen metabolism simultaneous monitoring MAP, CVP, heart output (CO), urine output and heart rate changes. Results MAP,CVP in both groups increased 30 min, 60 min, 120 min after injection. Furthermore the treatment group increased than significantly higher the control group (P <0.05 ). Heart rate in both groups decreased 30 min and 60 min after injection. CO in the treatment group was higher 60 min,120 min after injection than that in the control group (P <0.05 ). DO2, VO2 in the treatment group was higher 30 min ,60 min after injection than that in the control group (P <0.05 ). Condusion Perioperative penehyclidine in the treatment of acute hemorrhagic shock patients is effective for oxygen and oxygen utilization and reduces lactic acidosis and restore normal metabolism.
Keywords：Hemorrhagic shockPerioperafivePenehyclidimeBlood LactateOxygen metabolism
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 457-459 )