Correlation between plasma asymmetric dimethylargiuine and cerebral vasospasm after subarachnoid hemorrhage
CONG Jian-jun
ZHANG Tian-xi
GAO Bao-shan
CHANG Qing-yong
QIAN Sheng-wei
ZHANG Ji-zhi
JIN Dian-shi
HUANG Kun
QU Kai
ZHOU Jing-bin
Abstract：Objective To detect plasma concentrations of asymmetrical dimethylarginine (ADMA) at different time points after subarachnoid hemorrhage (SAH) and to further observe the possible function of ADMA in the pathogenesis of cerebral vasospasm after SAH. Methods Plasma ADMA concentrations was measured in patients who were diagnosed SAH (n= 38) at the different period (1-3 days,4-7 days and 14-21 days after hemorrhage) by Sandwich enzyme immunoassay technique and the blood flow rate was observed in intracranial artery by TCD, to observe the cerebral vasospasm continuously or intermittently. These patients were seperated into two groups according to the occurrence of cerebra] vasospasm. Healthy persons (n=20) after physical examine were allocated to be a control group. Results The mean density in vasospasm-sroup was obviously higher than that in control group (P< 0.01). The mean density in non-vasospasm-group was slightly higher than the one in control group (P>0.05). Cerebral vasospasm occurred in 2 cases during 1-3 days, in 28 cases during 4-7days and in 1 case after 14-21 days. The ADMA in 4-7 day group was obviously higher than that in other groups. There was statistical significance among the 3 groups. (P<0.01) . 2 patients died of disruption of aneurysm, 1 patient died of cerebral hernia, 6 patients had good outcome after therapies despite of newly cerebral infarct and others fully recovered. Condusion AMDA participates in the pathological process of SAH and is correlated with delayed cerebral vasospasm.
Keywords：Subaraclmoid hemorrhageAsymmetrical dimethylarginineCerebral vasospasm
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 431-433 )