Tianeptine combined with flupentxol melitracen for depressive disorder
LI Zhen
HU Meng
ZHANG Shun-ying
LI Zhe
REN Lan-zhen
TAN Qi
ZHANG Zhong-yin
CHEN Hao
Abstract：Objective To observe the effect of new method of Tianeptine combined with flupontxol melitra-cen for depressive disorder. Methods A total of 360 patients were randomly divided into four groups. Group A: 110 patients with Tianeptine and Flupontixol and Melitracen; Group B: 95 patients with Fluoxetine and Flupentixol and Melitracen; Group C: 72 patients with Tianeptine; Group D: 83 patients with Fhioxetine. The effects were as-sessed at the end of 1, 2, 4, 6 week after treatment. The treatment was considered effective if HAMD decreased more than 50%. The safety was evaluated with SERS, liver and kidney function test and ECG. Results The total effective response rate was 89.09% in group A, 78.94% in group B, 73.61% in group C and 66.27% in group D, respectively. The curative rate was significantly higher in the group A than that in other groups (A & B: x2=3.98, P<0.05; A & C:2 =7.37,P<0.01 ; A & D:2=15.00,P <0.01). The early curative effective re-sponse occurred only in group A after one week's treatment with HAMD. All the patients in the study have symptoms of dry mouth,headache and constipation without significance (P > 0.05 ). Conclusion Combination of Tianeptine and Flupontixol and Melitracen showes satisfactory curative effect and safety for depressive disorder.
Keywords：Depressive disorderTianeptionMelitracenFlupentixol
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 401-404 )