Pancreatic profile of inflammation in a murine model of metabolic endotoxemia
YU Meng
XU Jing-yi
ZHANG Yi-fei
ZHANG Qing
ZHANG Xiao-qing
DUAN Wei
Abstract：Objective To expore the feature of pancreatic inflammation induced in a murine model of endotoxemia. Methods Metabolic endotoxemia (ME) was elicited in male C57BL/6 mice following subcutaneous implantation of an osmotic minipump, through which bacterial lipopolysaccharide (LPS) was infused at a daily rate of 300 mg/kg body weight for a total of 14 days. In the end of the experiment, the fast plasma levels of glucose and insulin, the expression of a number of inflammation-related genes, as well as other selected indices were determined. Results Significantly increased levels of net increase of body weight, fast plasma glucose and insulin, and insulin resistance were found in the group of ME mice, compared with the control mice infused with normal saline. Meanwhile, the pancreatic gene expression of adiponectin, IL-6, MCP-1, and CCR2 was also found to be significantly increased in the ME mice. Conclusion Metabolic endotoxemia can induce local inflammatory response in the pancreas, which may interfere with the pancreatic insulin production.
Keywords：Metabolic endotoxemiaPancreatic inflammationInsulin resistance
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 374-376 )