Protection of p38MAPK inhibitor against myocardial injury in septic rats
LE Sheng
ZHANG Shun-ling
LIU Zhi-hong
MA Zhong-fu
Abstract：Objective To investigate the protection function of p38MAPK inhibitor against myocardial inju-ry in sepsis. Methods The cecal ligation and puncture was adopted to build up sepsis model. The levels of serum CK-MB,TNF-alpha and IL-lbeta at different time points were observed. Results The levels of CK-MB,TNF-alpha and IL-1 beta increased significantly after the CLP operation. The levels of TNF-alpha and IL-1 beta was significantly relat-ed to CK-MB. After administering p38MAPK inhibitor and SB203580, the levels of TNF-alpha and IL-1 beta decreased significantly and the myocardial injury was alleviated. Condusion Excessive secretion of TNF-alpha and IL-1 beta are the main cause of myocardial injury in sepsis. The regulation of the p38MAPK pathway may protect myocardial injury.
Keywords：SepsisInterleukin-1βTumor necrosis factor-alphaMyocardial injury
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 324-326 )