Comparison of Escitalopram and Paroxetine for patient with first-episode climacteric depression
JIANG Xiao-yan
REN Kai
ZHAO Xi-wu
Abstract：Objective To study the efficacy and safety of escitalopram and paroxetine for patients with first-episode climacteric depression. Methods A 8-week double-blind study was conducted, including 70 female patients suffering from climacteric first-episode depression. Subjects were randomly assigned to either escitalopram ( n = 35 ) or paroxetine ( n = 35 ). All subjects were evaluated with Hamilton Rating Scale for Depression ( HAMD- 17) , Hamilton Rating Scale for Anxiety ( HAMA), and Treatment Emergent Symptom scale (TESS) at baseline, 1,2,3,4,6,8 weeks after treatment. The study lasted for 8 weeks. Results The response rates between two groups (escitalopram 88.23% paroxetine 79.41% ) were similar. Each group had a lost case. There were significant differences on the scores of HAMD between the tow groups at the 1st and 2nd weeks, and HAMA at the 1st week after treatment. Escitalopram group was significantly lower than paroxetine group in sleepiness, dry mouth, tremor.Conclusion Escitalopram has rapid response, strong anti-depressive effect in female climacteric first-episode patients.
Keywords：EseitalopramParoxetineFemale climactericFirst-episode depression
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 282-283 )