The clinical efficacy of Propofol on severe hypercapnic respiratory failure in psychopathy during mechanical ventilation
WANG Yang-shun
LIANG Qing
YANG Hang
ZHENG Yan-hui
WU Xiang-hong
Abstract：Objective To study patients with chronic obstructive pulmonary diseases(COPD) with severe hypercapnic respiratory failure for Sedation in psychopathy during mechanical ventilation. Methods Forty-four cases of COPD with severe hypercapnic respiratory failure were divided into two groups, patients (n = 22) inControl The comparison was made on the changes of pH, PaO2, PaCO2in the arterial blood gas before and after the treatment 0. 5 h, 1 h, between the two groups. And also the changes of Pmax, Ppalt, PEF, FEV1/ FVC in pulmonary function between the two groups. Results Significant differences were found in the Propofol group of the improvement of pH, PaO2, PaO2/FiO2, PEF, FEV1/ FVC in pulmonary function and the decreased value of PaCO2, Pmax, Ppahbefore and after the treatment, compared with the control group (P < 0. 05～0. 01). Conclusion Propofol infusion have an excellent effect for sedation in ventilation patients with COPD with severe hypercapnic respiratory failure, can decrease airway resistance, improve the oxygenation in lung, Also can maintain the coordination between spontaneous breath and mechanic ventilation in psychopathy.
Keywords：PropofolPsychopathyVentilationRespiratory failurePulmonary function
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 185-187 )