Association between telomerase activity,p53 tumor suppressor gene and essential hypertension
LIN Shenghui
CHEN Hui
BAI Yuru
Abstract：Objective To investigate the telomerase activity of peripheral blood mononuclear cells in patients with essential hypertension,and to detect the mutation of p53 tumor suppressor gene.Methods The telomerase activity of peripheral blood mononuclear cells in 75 hypertensive and 50 normotensive was measured by telomerase-PCR-ELISA assay.The mutation of p53 tumor suppressor was detected by PCR-SSCP.Results The telomerase activity of peripheral blood mononuelear cells in hypertensive group were significantly increased than those in control group.Logistic regression study showed that the main influenced factors were age,diastolic blood pressure and the mutation of p53 tumor suppressor.The mutation of p53 tumor suppressor gene may increase the telomerase activity.The telomerase activity was correlated with the severity of hypertension and may be a prognostic risk factor.The increased telomerase activity may be related to the target organ injure of essential hypertension.Conclusion The telomerase activity was a mark of cellular proliferation activity in molecular level.It may be an important factor in the pathogenesis of essential hypertension.Meanwhile,the up-regulation of telomerase activity may be one of the risk factors in essential hypertension.
Keywords：Essential hypertensionTelomerasep53 tumor suppressor protein
Publication Date：2009-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 25-26 )