Combined Lamivudine and Adefovir for treatment of hepatitis B and cirrhosis
FENG Ying
Abstract：Objective To investigate the clinical effect of Combined Lamivudine and Adefovir for hepatitis B and cirrhosis.nethotis Sixty-nine patients of hepatitis B and cirrhosis were enrolled.including 43 initial treatment cases and 6 Lamivudine-resistant cases.The initially treated patients took Lamivudine 100 mg/d and Adefovir 10 mg/d simultaneously.Meanwhile the Lamivudine.resistant patients took lamivudine before taking Adefovir 10 mg/d.Liver function Was monitored,and the HBV-DNA's level and the Child-Pugh grade's change 3、6、1 months before and after therapy.Results The HBV-DNA decreased log copy/ml 1 months after treatment.ALT,AST,TBIL dropped down significantly after the combined use of Lamivudine and Adefovir.ALB rised and Child-Pugh scores reduced.Conciusion The combined use of Lamivudine and Adefovir is safe and effeetive for hepatitis B and cirrhosis.
Keywords：Hepatitis BCirrhosisLamivudineAdefovir
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 773-774 )