Combined lansoprazole with mospride in treatment of aged reflux esophagitis
WEI Jin-qi
L(U) Wei-hua
BIAN Zhuang
ZHOU Huai-li
CHEN Hong-jiang
Abstract：Objective To observe the effect of lansoprazole with mospride on reflux esophagitis.Methods Eighty patients with endoscopically proven reflux esophagitis were assessed in our hospiml with lansoprazole 30 mg once daily and mospride 5 mg three times a day.Reflux symptoms including regurgitation,heartburn and food reflux were evaluated during visits after 1,and 4 and 8 weeks.At the eighth week,endoscopy Was performed to study the healing rate,and a follow-up Was taken at 1,3,6 and 1 months after the treatment.Results After one-week treatment with lansoprazole with mospride,all symptoms had been improved,and symptom scores were greatly decreased(P＜0.01).Symptom relief was achieved by 6.5%,86.5%and 9.5%after,4 and 8 weeks respectively.At the end of the treatment,the endoscopic healing rate was 9.86%in esophagitis type Ⅰ,which Was much hiigher than type Ⅱ of75.76%and type Ⅲ of 54.54%(P＜0.05).The symptoms relapse rate in the 1st,3rd,6th and 1th month after the treatment Was 5.1%,17.33%,45.83%and 76.81%(53/69).Twelve months after the treatment,the esophagitis proved by endoscopy waft 79.17%,in which,44.7%for type I,34.1% for type Ⅱ and 1.05%for type III There were no obvious side effects.Conclusion Lansoprazole with mospride is effective in the treatment of aged reflux esophagitis.
Keywords：Reflux esophagitisLansoprazoleMospride
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 769-771 )