JAK2V617F mutation in patients with polycythemia vera
QIAO Na
YANG Lin-hua
Abstract：Objective To observe the JAK2V617F mutation in polycythemia vera.Methods Genomic DNA were extracted from 20 samples of peripherd blood or bone marrow from patients of PV.Allele specific polymerase chain reaction(AS-PCR)was used to analyze the genomic DNA and JAK2V617F mutation was detected with gel electrophokesis.A retrospective study was performed to explore the correlation between JAK2V617F mutation and hematologic features.Results The JAK2V671F mutation Wag identified in 14 of 20 Polyeythemia vera.The results of PCR products from selected samples were confirmed by sequence analysis.PV patients with JAK2V617F mutation had in creased white blood cell and platelet counts.Conclusion JAK2V617F mutation were in a significant percentage of samples with the polycythemia vera.PV Patients with JAK2V617F mutation had increased white cell and platelet counts.
Keywords：Polycythemia veraJAK2V617F mutation
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 685-686 )