Expression and clinical significance of Caspase-9 and Ki-67 In hepatocellular carcinoma
CHEN Lian-zhou
LI Yun-quan
SITU Miao-qiong
YAN Shu-hong
LI Wen
WANG Qian
Abstract：Objective To observe the expression and clinical significance of Cagpage-9 and Ki-67 in hepato-cellular carcinoma(HCC).Methods Expression of Cagpage-9 and Ki-67 was detected by tissue microarray and immunohistochemical method in 76 HCC tissues and 38 normal liver tissues.Results The expressions of Caspage-9 in HCC tissues(55.3%)was significantly lower than that in normal tissues(78.9%)(P＜0.05)and was correlated with Edmondson,s histological grade of carcinoma(P＜0.05),but there was no correlation among patients,age,gender,diameter,metastasis and HBsAg expression(P＞0.05).The expression rate of Ki-67 in HCC tissues(53.9%)was significantly higher than in normal liver tissues(13.2%)(P＜0.01),and was correlated with Edmondson,s histological grade and metastasis of carcinoma(P＜0.05).There was no correlation among patients,age,sex and HBsAg expression(P＞0.05).Meanwhile,expressions of Caspage-9 wag negative correlated with Ki-67(r=-0.300,P=0.008).Conclusion Low Caspage-9 expression and high Ki-67 expression may involved in the pathological process of cell apoptosis and proliferation,and play an important role in occurrence and progression of hepatocellular carcinoma.
Keywords：Hepatocellular carcinomaTissue micmarrayImmunohistochemitry
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 657-658 )