Fosinopril and simvastatin used alone or in combination for treating diabetic nephropathy
LIU Yu-cai
Abstract：Objective To assess the lenal protective effect of simvastatin and fosinopril used alone or in combination for treating diabetic nephropathy.Methods Ninety patients were randomly divided into three groups:30 patients of fosinopril group were treated with fosinopril 10 mg;30 patients of simvastatin group were treated with simvastatin 20 mg;30 patients in combination therapy group were treated with simvastation 20 mg and fosinopril 10 mg.All patients in each group received the correlative therapy for 24 weeks.The urinary albumin excretion rate (UAER),serum albumin(Alb),creatinine clearance(Ccr),serum creatinine(Scr),blood lipid and blood pressure were observed and recorded before and after treatment.Results After treatment,UAER,urine protein(UPT) decreased and the Alb increased in all three groups(P＜0.01).But the UAER decreased in combination therapy group more than those in fosinopril group and simvastatin group(P＜0.01).Reduction of UPT and Alb in combination therapy group Was more than those in other two groups(P＜0.01,P＜0.05).The Ccr and fasting blood glucose decreased in all groups but showed no significant difference(P＞0.05).The blood lipid and pressure increased in all three groups(P＜0.01),especially in combination therapy group.Conclusion Simvastatin and fosinopril in combination therapy is superior to monotherapy in the treatment of diabetic nephropathy.
Keywords：Diabetic nephropathySimvastatinFosinopril
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 533-535 )