Nutritional status,serum leptin,tumor necrosis factor and lung function in patients with chronic obstructive pulmonary disease
HUANG Yi
QIU Dan
LIU Zhen-feng
CHEN Dai-gang
LI Xiao-ping
LIU Jian-ying
Abstract：Objective To investigate the correlation among serum leptin,tumor necrosis factor,lung function and nutrition status in patients with chronic obstructive pulmonary disease(COPD).Methods Fifty COPD patients in stable stage were enrolled,including 18 malnutritional cases(group Ⅰ),24 normal body weight cases (groupⅡ)and 8 overweight and obesity cases(groupⅢ).Meanwhile 13 healthy cases were included as the control group.Body mass index(BMI),serum leptin,Tumor necrosis factor-α(TNF-α)and First forced expiratory volume (FEV1)were measured.Results Serum leptin level was significantly lower in group Ⅰ than that in group Ⅱ and group Ⅲ(P＜0.01).There was no significant difference between group Ⅲ and control group(P＞0.05).Serum TNF-αlevel was significantly higher in group Ⅰ than that in group Ⅱ and group Ⅲ(P＜0.05);there was no significant difference of TNF-αlevel among group Ⅱ,group Ⅲ and control group(P＞0.05);FEV1 was significantly lower in group Ⅰ than that in group Ⅱ,group Ⅲ and control group(P＜0.01),there were no statistically significant of FEV1 among group Ⅱ,group Ⅲ and control group(P＞0.05).The FEV1 in group Ⅰ showed a negative correlation with TNF-α.Moreover the FEV1 in group Ⅲ showed a negative correction with leptin.Conclusion The nutrition status in patients with COPD was related with serum leptin level.The lung function in patients with malnutritionul COPD was correction with serum TNF-αlevel.The lung function in patients with overweight and obesity was related with serum leptin.
Keywords：Chronic obstructive pulmonary diseaseLeptinTumor necrosis factor-αFirst forced expiratory volumeLung function
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 528-530 )