The change of laminin B1mRNA in experimental streptozotocin-induced diabetic nephropathy rats and its regulation by puerarin
HE Mei-ying
YIN Shu-dong
Abstract：Objective To observe the effect of Puerarin on laminin B1mRNA in Streptozotoein-induced diabetic nephropathy rats.Methods Rats were randomly dirided into control and experimental groups.The latter was divided into two subgroups,namely diabetes and Puerarin groups.Both groups were treated for 12 weeks.We studied blood glucose levels,urinary albumin excretion rate within 24 hours.creatinine clearance rate,and expression of laminin B1 gene in kidney tissue determined by in situ hybridization analysis during and after the treatment.Results All rats in experimental groups exhibit renal dysfunction.Urinary albumin excretion rate,creatinine cleKrance rate,end products of lamininin B1 mRNA in diabetes and Puerarin groups were significantly different as compared with that in control groups.Conclusion Puerarin plays a certain role in the protection of kidneys in diabetic rats via inhibiting the expression of kidney lamininin B1.
Keywords：Diabetic nephropathyPuerarinLamininB1Gene expression
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 454-456 )