Effects of carvedilol on collagen remodeling of non-infarction zone in rat model of acute myocardial Infarction
YIN Cheng-qian
ZHUANG Xiao-feng
LI Zhi-zhong
ZHANG Jing-mei
Abstract：Objective To observe the effects of carvedilol on the eollagen remodeling of non-infarction zone in rat model of acute myocardial infarction (AMI). Methods AMI model was established with ligation of anterior descending coronary artery in female SD rats. 24 hours after operation, 83 survivors were randomly divided into AMI control (MI group, n = 43 ), carvedilol [10mg/(kg. d)] treatment (C group, n = 40) group which included a sham-operated group(S group, n = 27). Furthermore, according to observation time, each group was divided into two subgroups: M148 h group, MI4W group; C48h group, C4W group; S48 h group, S4W group. Carvedilol was given to group C by gastric gavage 24h after ligation. The collagen volume fraction (CVF) of type Ⅰ, Ⅲ collagen was detected with immunohistochemistry, in the non-infarction zone (NIZ) of left ventricle. Results Compared with sham-operated 48h group, in MI 48h group, systolic blood pressure (SBP), mean aortic pressure (MAP)、diastolic blood pressure (DBP) and left ventricular systolic pressure (LVSP) and the maximum rate rise of left ventrieular pressure(±dp/dt) significantly decreased (P＜0.05 or P＜0.01), while left ventricular end diastolic pressure(LVEDP) significantly increased(6.06±4.64 vs 1.31±2.67 ,P＜0.05). Compared with sham-operated 4w group, in MI 4w group, only LVSP, ±dp/dt and heart rate significantly decreased (P＜0.05 or P＜0.01), but LVEDP was higher than that of MI48h (19.86±12.76 vs 6.06±4.64 ,P＜0.01). Meanwhile, CVF of type Ⅰ, Ⅲ significantly increased(P＜0.05 or P＜0.01). Compared with MI 48h group, LVSP, ±dp/dt and heart rate significantly decreased in C48h group, but LVEDP did not change. However, compared with MI 4w group, LVEDP(11.93±9.79vs 19.86±12.76) and CVF of type Ⅰ ,Ⅲ(3.82.±1.16vs8.10±1.77;2.67±0.82 vs5.26±1.87 ; respectively) deereased in CAw group (P＜0.05 or P＜0.01), but LVSP and ±dp/dt did not change.Condusion As abnormal hemodynamic and left ventricular function developed after AMI in rats, CVF of type Ⅰ ,Ⅲ increased. 4 weeks' treatment of carvedilol could not only decrease LVEDP, improve left ventrieular function and hemodynamic, but also reduce the increase of CVF of type Ⅰ、Ⅲ in the left ventricle non-infarction zone of rats after AMI.
Keywords：Myocardial infarctionVentricle remodelingCollagenCarvedilo
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 403-406 )