Influential factors of bone mineral eensity in female patients with Polymyositis and Dermatomyositis

HONG Xiao-ping; XIAO Xue-lv; LIU Dong-zhou; SUN Bao-dong; TAN Yan-hong

doi:10.3760/cma.j.issn.1673-4777.2008.06.013

Abstract：Objective To observe the change of bone mineral density in female patients with Polymyositis and Dermatomyositis and to assess the influence of the clinical index, the dosage and duration of glucocorticoid on bone mineral density. Methods Bone mineral density was measured at the femur neck, Ward's trigone, trochanter and left distal radius in 36 female patients with Polymyositis and Dermatomyositis by dual energy X-ray absorptionmetry. The clinical manifestation, laboratory data, the dosage and duration of glucocorticoid were also recorded at the same time. Results The bone loss in female patients with Polymyositis and Dermatomyositis was more significant than that in healthy controls (P < 0.05 ). Abnormal bone mass occurred more in elderly Polymyositis and Dermatomyositis patients. The duration of glucocorticoid in Polymyositis and Dermatomyositis patients was longer than those in normal controls (P < 0. 05 ). The accumulated dose of glucocorticoid in Polymyositis and Dermatomyositis patients was higher than those in normal controls( P < 0.05 ). The incidence rate of osteoporosis in the amenerrheic patients was higher than that in patients who were not amenerrheic ( P < 0.05 ). There was linear regression relationship between the duration of glucocorticoid treatment, accumulated dose of glueocorticoid and bone mineral density in the femur neck by multiple linear regression analysis. Conclusion The incidence of osteoporosis in female patients with Polymyositis and Dermatomyositis is higher than that in controls. Osteoporosis occurs more frequently in amenorrheal women. The duration of glucocorticoid treatment, and accumulated doses of glucocorticoid are risk factors for bone mineral density decrease in female patients with Polymyositis and Dermatomyositis.