Progression of adult moyamoya disease
GE Zhao-li
BAI Run-tao
HAN Man-fu
Abstract：Objective To observe the clinical progression of adult moyamoya disease (MMD). Methods Forty MMD patients were enrolled. Among them, 33 patients were confirmed with typical " bilateral" moyamoya disease. The other 7 patients were suspected of "unilateral" moyamoya disease. All cases were followed up with a mean period of 70.2 months. Magnetic Resonance Imaging (MRI) and Magnetic Resonance Angiography (MRA)were repeated every 1 to 2 years, and Digital subtraction angiography (DSA) was performed when MRI and MRA showed possible disease progression. Results Disease progression occurred in 8 of 40 patients (20%) during the follow-ups. Occlusive arterial lesions progressed in both anterior and posterior brain vessels. In both bilateral and unilateral groups. 7 of 8 patients developed ischemic or hemorrhagic events. Between progression group and stable group, no significant difference was shown in terms of gender, age, onset symptoms( Ischemia or Bleeding) ,type of disease (bilateral or single-sided) and bypass surgery. Conclusion The incidence of progression of adult moyamoya disease is much higher than previously recognized, Neurological and radiological follow-ups would be essential in adult moyamoya patients for stroke prevention and better outcomes.
Keywords：Moyamoya diseaseAdult
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 338-340 )