Expression and clinical signification of PTEN tumor suppressor gene in endometrial cancers
LIU Da-ju
ZHANG Xin-yu
Abstract：Objective To discuss the role of PTEN in the carcinogenesis and development of ndometrial cancers (EC).and to observe the correlation between PTEN protein expression and the clinical or pathological features in EC.Methods PTEN protein expression was detected in 15 normal human endometrium tissues.15 preeancer tissues and 40 primary EC tissues respectively by immuno histochemical method(SP method).Results PTEN protein expression were found in 14 of 15(93.3%)normal endometrium,10 0f 15(66.7%) precancers and 18 of 40 (45.0%) EC.The difference of PTEN protein concentration among the three groups was statistically significant(P＜0.05).PTEN protein expression varies according to tumors types.The expression in endometrial adenocarcinomas (37.1%) was much lower than in other types of EC (P＜0.05).In contrast,no significant differences of PTEN protein expression were observed in FIGO stage,pathologic grade,myometrial invasion and lymph node metastatic.All 40 EC patients were followed up after operation.10 patients of them died.The mortality in PTEN positive stain (5.6%) was significant lower than in PTEN negative stain(40.9%)(P＜0.05).Conclusion The PTEN protein expression in different endometrium tissues iS important for the pathogenesis of ECs,and the loss of PTEN function due to the mutational or other mechanisms iS possibly the earliest event in the pathogenesis of endometrial adenocarcinoma.Moreover.PTEN expression iS related to the prognosis of EC.
Keywords：Endometrial cancerTumor suppressor gene of phosphatase and tensin homolog deleted on chromosome ten
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 299-301 )