The serum changes of TNF-α,IL-6 and IL-10 in the intensive care patient
XIU Yu-fang
WAN Xian-yao
Abstract：Objective To analyze the correlation between APACHE Ⅲ Score and serum changes of TNF-α, IL-6 and IL-10 in patients in intensive care unit. Methods Fourty-one patients (study group) transferred to ICU were divided into survival group and death group. Blood samples were collected from the study subjects and 20 control subjects respectly on the 1 st and 7th day after admission and were examined for the levels of TNF-α, IL-6 and IL-10 with enzyme-linked immunosorbent assay (ELISA). Meanwhile, APACHE Ⅲ Score for each patient was recorded everyday. Results The serum levels of TNF-α, IL-6 and IL-10 in study group were significantly higher than that in control group in the first admission day(P ＜ 0.05 ). TNF-α and IL-6 were decreased on the 7th day while IL-10 was still high. According to APACHE Ⅲ Score, the scores in death group were all significantly higher than that in survival Group on both days. The serum levels of TNF-α,IL-6 and IL-10 were relative to APACHE Ⅲ score ( P＜ 0.05 ). Conclusion Pro-inflammatory cytokines ( TNF-α, IL-6 ) and anti-inflammatory cytokines ( IL-10) are important parameters for the prognosis of the intensive care patient. Combined with APACHE Ⅲ score,TNF-α,IL-6 and IL-10 levels can be used as assistant indexes for evaluation of the severity of critical patient.
Keywords：CytokinesTumor necrosis factor-αInterluekin-6Interluekin-10
Publication Date：2008-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：2( 286-287 )