Expression of GINS4 in prostate cancer tissues and its impact on cancer cell proliferation and migration capabilities
WANG Pengyu
WEI Zhongqing
YU Hao
SHI Guowei
Abstract：Objective To investigate the impact of GINS4 expression levels on prostate cell cancer viability,prolifera-tion,and migration capabilities.Methods We used public databases to perform bioinformaties analysis of GINS4 expression in human tumor and normal tissues.Prostate cancer cell lines with stable GINS4 knockdown were established through targeted gene silencing.Cellular viability was assessed via CCK-8 assay,proliferative capacity through colony formation assay,and migratory potential using scratch wound healing assays.Results GINS4 exhibited significantly elevated expression in urological tumor tis-sues relative to normal counterparts(P＜0.05).Silencing GINS4 expression resulted in concurrent downregulation of p-AKT.Functional assays demonstrated marked suppression of cellular viability,proliferative activity,and migratory capacity in GINS4-deficient prostate cancer cells(P＜0.05).Conclusion In vitro experimental evidence indicates that GINS4 inhibition sub-stantially attenuates prostate cancer cell viability,proliferation,and migration.Mechanistically,GINS4 may exert oncogenic effects through modulation of the PI3 K-AKT signaling pathway,suggesting its potential involvement in prostate carcinogenesis and progression.
Keywords：GINS4prostate cancerPI3K-AKT signaling pathwayproliferationmigration
Publication Date：2026-02-20
Online Publishing Date：2026-03-27(First online date of this platform, not the publication date of the document)
Pages：6( 112-117 )