Liquid-liquid phase separation in andrological diseases:Advances in studies
DENG Hang
MA Ziyang
ZHANG Peihai
Abstract：Liquid-liquid phase separation(LLPS)refers to the process by which biological macromolecules such as cellu-lar proteins and nucleic acids condense into droplet-like condensations to form different liquid phases.This process is regulated by a variety of factors,such as pH,light intensity,temperature,salt concentration,osmotic pressure,molecular crowding,post-translational modifications,etc.LLPS is a ubiquitous and vital phenomenon in cell life activities,which is involved in the forma-tion of membrane-free organelles,gene transcription regulation,cell signal transduction and other processes.In recent years,studies have shown that LLPS is involved in the regulation of many male urinary and reproductive systems,such as infertility,erectile dysfunction,prostate cancer,etc.This article reviews the role of LLPS in some male urinary and reproductive system diseases,and discusses the unanswered questions and future development trends in this field.
Keywords：liquid-liquid phase separationmale urinary systemmale reproductive systemproteinregulation
Publication Date：2026-01-20
Online Publishing Date：2026-03-24(First online date of this platform, not the publication date of the document)
Pages：7( 76-82 )