Evaluation of 68Ga-PSMA PET/CT-guided single-needle transgluteal targeted biopsy in the precise diagnosis of prostate lesions
ZHANG Lele
ZHU Jiageng
YAO Xiaochen
ZHAO Zhenyu
AI Shuyue
ZANG Shiming
SONG Jieping
NI Yudan
QIAN Xinyu
GUAN Zisong
SUN Hongbin
WANG Feng
Abstract：Objective The aim of this study is to evaluate the performance of 68Ga-PSMA PET/CT-guided transgluteal single-needle targeted biopsy(PSMA-TB)for detecting prostate cancer(PCa)and clinically significant prostate cancer(csPCa),in comparison with transrectal ultrasound-guided biopsy(TRUS-GB).Methods A retrospective analysis was conducted on 460 cases of suspected pros-tate cancer admitted to Nanjing First Hospital between January 2018 and June 2024.According to the biopsy method,the patients were di-vided into a TRUS-GB group(n=324)and a PSMA-TB group(n=136).Clinical,imaging,biopsy pathological,and postoperative pathological data after prostatectomy were collected for statistical analysis.Results There was no significant difference in age and SUVmax between the two groups(P＞0.05).PSA levels and PI-RADS scores were significantly higher in the PSMA-TB group than those of the TRUS-GB group(P＜0.05).The true positive rates of PSMA-TB for PCa and csPCa were higher than those of TRUS-GB(PCa:76.2％vs 38.0％,P＜0.01;csPCa:71.3％vs 28.4％,P＜0.01).Within the PSMA-TB group,the true positive rates for PCa and csPCa were high-er than the false negative rates(P＜0.01).The pathological consistency between PSMA-TB biopsy and postoperative prostatectomy speci-mens was higher than that of TRUS-GB(P=0.004 1).Conclusion PSMA-TB demonstrates higher diagnostic accuracy for both PCa and csPCa compared with TRUS-GB.Characterized by its minimal invasiveness and higher consistency with postoperative radical prostatectomy pathology,PSMA-TB represents an optimal approach for the precise diagnosis of suspected prostate lesions.
Keywords：prostate cancertargeted biopsyprostate-specific membrane antigenpositron emission tomographytrans-gluteal approach
Publication Date：2026-01-20
Online Publishing Date：2026-03-24(First online date of this platform, not the publication date of the document)
Pages：6( 21-26 )