Nicotinamide Adenine Dinucleotide and Male Reproductive Health
HUANG Zhengkai
YAO Fan
FU Dian
SHANG Xuejun
Abstract：Nicotinamide adenine dinucleotide(NAD+)is a crucial coenzyme in cells,which participates in physiological processes including cellular energy metabolism,DNA repair,cell growth,and cell death.It can regulate reproductive functions by modulating oxidative stress,maintaining redox balance,and through NAD-dependent enzymes(such as the Sirtuins and poly ADP-ribose polymerases).Recent research has discovered that NAD+precursor supplements have demonstrated favorable out-comes in preventing and treating male reproductive system disorders,such as oligospermia,asthenospermia,reproductive dys-functions caused by aging and diabetes,as well as oxidative damage during the process of sperm cryopreservation and thawing.Additionally,NAD+has also exhibited potential application value in the prevention and treatment of prostate cancer.This article presents a review on the role of NAD+in male reproductive health and provides a scientific basis for the development of new ther-apeutic strategies for andrological diseases.
Keywords：nicotinamide adenine dinucleotidemale reproductionoxidative stressprostate cancer
Publication Date：2025-12-20
Online Publishing Date：2026-01-22(First online date of this platform, not the publication date of the document)
Pages：7( 1137-1143 )