Challenges of advanced paternal age in fertility:Research progress on adverse pregnancy outcomes
LI Yunju
ZHAO Kai
ZHAO Yun
Abstract：With the development of social economy and the transformation of fertility concepts,male reproductive health is receiving increasing attention..This article reviews the impact of advanced paternal age on adverse pregnancy outcomes and the relevant research achievements in recent years.Existing evidence suggests that advanced paternal age may increase the risk of miscarriage,preterm birth,low birth weight,macrosomia,and birth defects.The mechanisms may be closely related to age-re-lated molecular changes such as epigenetic variations,gene mutations,and DNA fragmentation.At the same time,advanced pa-ternal age may also have adverse effects on the outcomes of assisted reproductive technology.Overall,most studies support the existence of a certain association between advanced paternal age and adverse pregnancy outcomes.However,the relevant evi-dence is still insufficient,and the research results are also inconsistent.In the future,large-scale prospective studies need to be carried out to further clarify the relationship between the two and provide a scientific basis for the reproductive assessment and clinical decision-making of advanced-aged men.
Keywords：advanced-aged menassisted reproductive technologyadverse pregnancy outcomesepigenetics
Publication Date：2025-12-20
Online Publishing Date：2026-01-22(First online date of this platform, not the publication date of the document)
Pages：6( 1119-1124 )