Paternal transmission of epigenetic information and its potential impact on offspring health
ZHENG Zilin
ZHANG Yifan
GUO Bingrou
ZUO Liandong
Abstract：Recent studies indicate that paternal exposures significantly affect offspring health.Adverse factors such as poor diet,toxin exposure,and stress can reduce semen quality and disrupt epigenetic marks in sperm,leading to changes in off-spring traits.Paternal transgenerational inheritance mainly occurs through epigenetic factors like DNA methylation,histone modi-fication,and non-coding RNAs.While researches have begun to reveal how sperm transmits epigenetic information,paternal epi-genetics largely remains correlational.Increasing concerns about environmental pollution and lifestyle changes have shifted focus to paternal sperm quality and its impact on offspring health before conception.Future studies should explore how different envi-ronmental and male infertility factors influence paternal epigenetics and how specific marks affect embryonic development,ulti-mately enhancing diagnostics,treatments,and preconception care.
Keywords：paternal exposuremale infertilityspermenvironmental factorsepigeneticsoffspring health
Publication Date：2025-11-20
Online Publishing Date：2025-12-18(First online date of this platform, not the publication date of the document)
Pages：5( 1027-1031 )