Causal relationship between insomnia and erectile dysfunction based on heart-kidney intersection theory:A two-sample Mendelian randomization study
QIU Ze-rui
OU Guang-yang
LIU Heng-jie
MA Wen-tao
HUANG Man-jie
WANG Neng
ZHOU Jun
ZHOU Qing
Abstract：Objective:Previous studies have shown that insomnia is closely related to erectile dysfunction(ED).However,the causal relationship between them is still unclear.Mendelian randomization(MR)provides a new method for studying the relationship between the two,and the theory of heart-kidney interaction in TCM provides a new idea for exploring the causal relationship between them.Methods:Based on the statistical data collected by genome-wide association studies(GWAS),the causal relationship be-tween insomnia and ED was discussed by MR.Inverse variance weighted(IVW)is the main analysis method,and weighted median(WME),simple mode(SM),weighted mode(WM)and MR Egger method were the supplementary analysis to evaluate the causal effect.MR-Egger intercept test,Cochran Q test and leave-one-out method were used in sensitivity analysis to verify the reliability of MR results.Results:Thirty-nine SNPs significantly related to insomnia were finally included for MR analysis.The results of IVW method in MR analysis showed that insomnia had a significant causal relationship with the increased risk of ED(OR=3.111,95％CI=1.566-6.181,P=1.193 × 10-3).The results obtained by MR-Egger method,WME method,WM method and SM method were consistent with IVW method in the direction of effect.The sensitivity results suggested that the results of this study were robust.Conclusion:Our study reveals the causal relationship between insomnia and ED,which provides a new basis for future clinical practice and prevention and treatment of ED.
Keywords：erection dysfunctioninsomniaMendelian randomizationheart-kidney interaction
Publication Date：2025-07-20
Online Publishing Date：2025-08-21(First online date of this platform, not the publication date of the document)
Pages：6( 597-602 )