Advances in early screening and diagnosis of prostate cancer
LI Ying-fan
LI Hong-xin
WANG Wei-fu
ZENG Fan-chang
Abstract：Prostate cancer is one of the most common tumor,with the disease progressing from inert to aggressive tumors,and rapidly progressing to castration-resistant prostate cancer.Early-stage prostate cancer is usually asymptomatic.And by the time that symptoms appear,the disease has progressed to an incurable stage.Therefore,early diagnosis and treatment is especially important to control prostate cancer,which prolongs the survival period of patients.Digital rectal examination and prostate-specific antigen have been widely used in the diagnosis of prostate cancer.However,there are certain limitations that lead to overdiagnosis and overtreat-ment.Although prostate needle biopsy is still the gold standard for diagnosing prostate cancer,with the wide application of multipara-metric magnetic resonance examination and PSMA-PET/CT and other technologies in recent years,as well as the emergence of new bio-markers with higher sensitivity and specificity,its status as the gold standard has been challenged.And the diagnostic mode of prostate cancer has also undergone great changes.On this basis,the radical prostatectomy without prostate needle biopsy has been attempted clinically to treat prostate cancer,which gains the good clinical results.This article provides a review of the latest research advances in early screening and diagnostic models for prostate cancer.
Keywords：prostate cancerearly diagnosisnew biomarkersmultiparametric magnetic resonance imagingtargeted biopsyliquid biopsyPSMA-PET/CT
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 462-467 )