Research progress on the mechanisms of male reproductive function damage by bisphenol A and traditional Chinese medicine intervention
HUANG Nian-wen
BAI Zun-guang
HONG Zhi-ming
BI Huan-zhou
Abstract：Bisphenol A(BPA)is a kind of exogenous chemicals presenting in the human living environment widely which af-fects the action of endocrine hormones in the human body.Numerous studies have shown that BPA has reproductive toxicity in the sper-matogenic function damage of the testes through a variety of mechanisms such as interfering with endocrine function,inducing oxidative stress,promoting spermatogonial cell apoptosis,destroying the integrity of the blood-testis barrier,and regulating epigenetic inherit-ance,thereby destroying male fertility.Relevant studies have shown that TCM can improve male fertility by reversing BPA-induced re-productive damage through multi-component,multi-target and multi-mechanisms.However,there is no systematic review on the mech-anism of TCM to reduce the reproductive toxicity of BPA.Based on the existing studies,this article will systematically introduce the mechanisms of BPA-induced reproductive impairment in men and the progress of TCM interventions,with a view to providing reference targets and research directions for the development of new Chinese medicines.
Keywords：bisphenol Areproductive toxicitytraditional Chinese medicinemechanism of actionmale infertility
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 457-461 )