Brain function and connection in patients with refractory overactive bladder and healthy population:Analysis based on resting-state functional MRI
ZHANG Yu-wei
FU Si-yi
LIU Yu-min
SONG Hui-hui
JIANG Peng
XU Jia
HU Bin
CHEN Yao
YIN Ling-xuan
YUAN Yun-yun
ZHENG Ya
GU Kai-yuan
TANG Yan-na
HUA Ye
FENG Ning-han
Abstract：Objective:To investigate the characteristics of central nervous system regulation in patients with refractory overac-tive bladder(rOAB)using resting-state functional magnetic resonance imaging(rs-fMRI),and to analyze the differences in brain function and connection between the patients and healthy population.Methods:From May 1 to November 30,2024,we performed rs-fMRI for 47 rOAB patients and another 47 matched healthy controls,documented relevant clinical data from all the participants and obtained their Overactive Bladder Symptom Scores(OABSS)and Overactive Bladder Questionnaire(OAB-Q)scores.Based on rs-fM-RI,we compared the results of Independent Component Analysis(ICA),amplitude of low-frequency fluctuations(ALFF),fractional amplitude of low-frequency fluctuations(fALFF),regional homogeneity(ReHo)and degree centrality(DC)between the rOAB pa-tients and healthy controls.Results:The rOAB patients,in comparison with the healthy controls,showed dramatically higher day-time urination frequency(11.64±3.85)vs(5.76±0.91),nighttime urination frequency(3.72±1.64)vs(0.31±0.47),OABSS(8.22±2.21)vs(0.64±0.78),OAB-Q1 score(20.85±5.28)vs(6.78±1.04),and OAB-Q2 score(45.04±12.11)vs(14.51±1.66)(all P＜0.01).No statistically significant differences were observed in the results of ICA and ALFF be-tween the right superior frontal and right middle frontal regions in the rOAB patients(P＞0.05),but fALFF,ReHo and DC were sig-nificantly decreased in the patients compared with those in the healthy controls(P＜0.01).Conclusion:Compared with healthy population,the functions and connection of the frontal superior right and frontal middle right brain regions in rOAB patients are signifi-cantly down-regulated,which may serve as new therapeutic targets.
Keywords：refractory overactive bladderresting-state functional magnetic resonance imagingbrain functional networkneuro-genic theorybrain-bladder axis
Publication Date：2025-01-19
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 39-44 )