Effects of Huang'e Capsules on type ⅢA prostatitis and inflammatory cytokines in the expressed prostatic secretion of the patient

OU Yang-fan; LIANG Yu-ru; XU pan; HUANG Wen-bin; HUANG Jian-fang; XIE Zuo-gang

doi:10.13263/j.cnki.nja.2024.12.013

Abstract：Objective:To investigate the clinical efficacy of Huang'e Capsules in the treatment of type Ⅲ A chronic prostatitis,and its effects on the levels of the inflammatory cytokines neutrophil elastase(NE),IL-8 and TGF-β1 in the expressed prostatic secre-tion(EPS)of the patients.Methods:We selected 120 patients with type Ⅲ A chronic prostatitis and randomly assigned them to medication with Huang'e Capsules(the trial group,n=60)or Levofloxacin and Tamsulosin(the control group,n=60),both for a course of 4 weeks.We obtained the NIH-CPSI scores and the levels of NE,IL-8 and TGF-β1 in the EPS,and compared them between the two groups before and after treatment.Results:Totally,116 of the patients completed the study,59 in the trial and 57 in the control group.The overall clinical effectiveness was significantly higher in the trial group than in the control(89.8％vs77.2％,P＜0.05).Compared with the baseline,the patients of the trial group showed significant decreases after treatment in the total NIH-CPSI scores(32.5±7.4 vs 13.2±5.1),pain symptom scores(13.7±3.9 vs 4.2±2.3),urination symptom scores(6.9±2.4 vs 5.1±3.2)and quality of life(QOL)scores(8.3±2.7 vs 3.7±1.5)(all P＜0.05),and so did the controls in the total NIH-CPSI scores(30.8±7.8 vs 13.7±3.9),pain symptom scores(14.2±4.1 vs 7.8±2.9),urination symptom scores(7.1±2.7 vs 4.9±3.4)and quality of life(QOL)scores(8.1±2.4 vs 5.6±1.9)(allP＜0.05),and the decreases were even more significant in the trial than in the control group in the pain symptom and QOL scores(P＜0.05).The patients of the trial group also exhibited a marked reduction after treatment in the contents of NE([1135.4±321.5]vs[347.6±207.3]ng/L,P＜0.05)and IL-8([974.9±231.6]vs[431.3±207.2]ng/L,P＜0.05)but an elevation in that of TGF-β1([591.0±172.1]vs[1 402.1±221.5]ng/L,P＜0.05)in the EPS,and so did the controls in the levels of NE([1052.8±280.3]vs[761.1±225.1]ng/L,P＜0.05),([1007.5±287.7]vs[775.7±182.5]ng/L,P＜0.05),([607.8±201.3]vs[871.3±192.5]ng/L,P＜0.05),with even more significant improvement in the trial than in the control group(P＜0.05).Conclusion:Huange Capsules has a significant clinical efficacy and safety in the treatment of type ⅢA prostatitis,which can effectively relieve the pain and urination symptoms and improve the levels of the inflammatory cytokines NE,IL-8 and TGF-β1 in the patients.