Pathogenesis of asthenozoospermia in males:Progress in research
QIAN Lin
LI Wen-xin
WANG Han-shu
JING Tao
Abstract：Asthenozoospermia is one of the major causes of male infertility,with complex pathogenesis,which involves abnor-malities in sperm morphology,signaling pathways,sperm motility-related energy metabolism,and other factors.Currently,extracellu-lar vesicles(EV)in the seminal plasma have been found with a positive effect on the spermatogenic process by releasing such self-en-capsulated molecules as DAN,RNA and proteins into target cells through direct fusion with the structure similar to the lipid bilayer on the surface,and thereby regulating their function.This article reviews the research progress in the pathogenesis of asthenozoospermia,aiming to provide some theoretical evidence for its further studies.
Keywords：asthenozoospermiasperm morphologysignaling pathwayenergy metabolism
Publication Date：2024-10-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 936-941 )