Mitochondrial damage and male reproductive dysfunction:Progress in research
LI Jin-dong
LIU Zhen-xiang
SHANG Xue-jun
Abstract：Mitochondria are the center of sperm metabolism and essential for all aspects of flagellar motility,capacitation,acro-some reaction and gametic fusion of sperm.Abnormalities in the mitochondrial ultrastructure,membrane potential,reactive oxygen spe-cies,Ca2+homoeostasis,sperm apoptosis,mitochondrial DNA,mitochondrial enzymes and proteomic activity can decrease sperm quality and even cause male infertility.This paper elucidates the impact of mitochondrial dysfunction on sperm by reviewing and analy-zing relevant literature on mitochondria and male reproductive function,aiming to provide some theoretical evidence for exploring effec-tive interventions for male reproductive dysfunction.
Keywords：mitochondriaspermmale infertilityreactive oxygen speciesapoptosismitochondrial DNAmitochondrial fu-sion/division
Publication Date：2024-08-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 744-749 )