Essential roles of fibroblast growth factors in male reproduction
LI Xiao-kun
Abstract：The testis serves as the reproductive gland in male mammals,primarily tasked with the production of sperm and syn-thesis of androgens.A complex signaling network consisting of various cell types,including germ cells,Sertoli cells,and Leydig cells,supports the structure and maintains the function of the testis.Apart from the hypothalamic-pituitary-gonadal axis,various sex hormones and cytokines are also implicated in the regulation of testicular function.The fibroblast growth factor(FGF)represents a crucial class of active cytokines that stimulate cell proliferation,induce tissue differentiation,and govern organ development.This review summari-zes the molecular mechanisms of FGF regulating testicular development and spermatogenesis and maintaining male fertility.
Keywords：fibroblast growth factormale reproductionregulatory mechanism
Publication Date：2024-01-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 3-8 )